A Novel saRNA Backbone for Reduced Cytotoxicity & Enhanced Payload Expression
Time: 12:30 pm
day: Conference Day One
Details:
- We have developed few strategies with novel saRNA backbones:
- To reduce dsRNA-induced toxicity and to increase payload expression through mutagenesis
- To regulate saRNA amplification and payload translation in a cell-type-specific manner
- HPV mRNA/saRNA therapeutic vaccines were developed and demonstrated both prophylactic and therapeutic efficacy in an HPV+ animal tumor model
