Unlocking the Potential of PBAE Nanoparticles: Advancements in mRNA Delivery for Targeted Immunization
Time: 5:00 pm
day: Conference Day One
Details:
- PBAEs can be synthesized with a wide range of chemical structures that have different properties
- PBAEs can be screened in a high-throughput manner to discover structures that can deliver mRNA to immune cells
- Optimized PBAE/mRNA nanoparticles can transfect immune cells selectively over other cell types after in vivo administration, without requiring ex vivo cell manipulation or manufacturing
- PBAE/mRNA nanoparticles can co-deliver multiple sequences and/or other types of nucleic acids, including nucleic acid-based adjuvants
- Nanoparticles containing mRNA sequences alone or along with adjuvants can safely and effectively immunize animals against an antigen(s) of interest
